Raw Talk Podcast

Skin disease does not always begin and end at the skin. Inflammatory and autoimmune processes can shape conditions ranging from psoriasis and eczema to systemic diseases with important dermatologic manifestations. In this episode of Raw Talk, we speak with dermatologist and researcher Dr. Anastasiya Muntyanu about the relationship between the immune system, inflammation and skin disease. We explore how these conditions develop, the role of environmental and biological factors, and how research is changing our understanding of inflammatory and autoimmune dermatology. Dr. Muntyanu also takes us inside the intersection of clinical dermatology and research, and discusses why studying the skin can provide important insights into processes occurring throughout the body. 

Executive Producer: Areej Mir

Acne is incredibly common, but there is no shortage of conflicting advice about what causes it and how it should be treated. In this episode of Raw Talk, we speak with Dr. Sam Hanna and Dr. Angela Duan about the science behind acne and how it is approached in clinical practice. We explore why acne develops, how treatment can differ from person to person, common misconceptions surrounding skincare and breakouts, and what patients should know when seeking care. We also discuss the broader impact acne can have beyond the skin and how our understanding and treatment of the condition continues to evolve. Whether you have experienced acne yourself or simply want to understand one of dermatology's most common conditions, this episode takes a closer look at what is really happening beneath the surface.

Executive Producer: Areej Mir.

Show Hosts: Areej Mir and Raeesah Mohammed. 

For patients facing life-threatening illness, distress can involve fear, grief, uncertainty, and questions of meaning. In Episode 136 Part 2, we speak with Dr. Emma Hapke from the Psychedelic Psychotherapy Research Group at UHN about psilocybin-assisted psychotherapy for end-of-life distress in patients with advanced cancer and their caregivers.

We also hear from Daryna Skybina, who shares her perspective as a patient and reflects on the human side of navigating serious illness. Together, these conversations highlight both the promise and complexity of psychedelic-assisted therapy.

Thank you to our production team: Avni Bhargava and Swapna Mylabathula (Show Hosts), Bellinda Yi (Content Creator), Tiffany Chien (Science Writer), Victoria Li (Audio Editing), Dana Huang (Graphic design and Promotions), and Nicole Chu (Executive Producer).

Once dismissed as relics of counterculture, psychedelics are now being studied for their potential role in mental health care. In Part 1 of episode 136, Avni and Swapna speak with Dr. Jarrett Rose and Dr. Rotem Petranker about the history, science, and evolving clinical landscape of psychedelics, from the early research boom of the 1960s to today’s renewed interest in psilocybin- and LSD-assisted therapy.

Together, they unpack how these compounds may affect the brain, why they are being studied for conditions such as depression, anxiety, PTSD, and substance use disorders, and why scientific rigour, regulation, and patient safety remain essential as the field moves from prohibition to protocol.

Thank you to our production team: Avni Bhargava and Swapna Mylabathula (Show Hosts), Bellinda Yi (Content Creator), Tiffany Chien (Science Writer), Victoria Li (Audio Editing), Dana Huang (Graphic design and Promotions), and Nicole Chu (Executive Producer).

When cancer treatment puts a patient’s reproductive future at risk, fertility preservation offers options, but only if people are informed early enough and can access care equitably. In this episode, Sonika and Julia investigate the science and realities of fertility preservation with Dr. Jenna Michaeli, an oncofertility specialist and clinician-scientist at Mount Sinai Fertility. She introduces the different preservation options available, including egg and embryo freezing, sperm banking, and a newer technique called ovarian tissue cryopreservation (OTC). Dr. Michaeli discusses some of the innovative models of care required for equitable access to OTC, such as transporting ovarian tissue to centralized cryobanks to expand access for patients in remote communities. Beyond the science, Dr. Michaeli emphasizes the emotional and ethical complexity of fertility preservation decisions, particularly for young patients and their families, and the importance of culturally sensitive counselling. She also addresses key barriers, including limited awareness, time-sensitive referrals, and gaps in funding for newer procedures like OTC. Tune in for an informative conversation about how fertility preservation needs to be better integrated into cancer treatment, and why equitable access remains a critical challenge.

 

Thank you to our production team: Sonika Kumari and Julia Wong (Show Hosts), Tesam Ahmed (Content Creator), Emily Forster (Science Writer), Nicole Chu (Audio Editing), Saleena Zedan (Graphic design and Promotions), and Nicole Chu (Executive Producer).

Deciding if and when to have children can be a major challenge and is even more difficult when facing the unrelenting pace of medical training. Long hours, rigid schedules, financial strain, and unspoken expectations often push family planning to the sidelines. In this episode, Sonika and Julia explore the realities of family planning and fertility preservation for medical trainees at different career stages. For an early career perspective, Sonika and Julia talk with Dr. Lauren Pickel, a first-year urology resident, who reflects on how little formal education she received around fertility and family planning while in medical school. She discusses how this education gap can significantly shape both personal and professional decisions. Looking at a later career medical professional, Sonika and Julia interview Dr. Niro Sivachandra, a retinal surgeon and clinician-scientist, who shares her experience regarding having children during residency, and how supportive leadership can help improve quality of life for many physicians and their families. Together, our guests unpack their hidden barriers, from fears about burdening colleagues to discouragement from following certain medical specialties. They emphasize the importance of workplace culture and policies which are supportive to both career and family development. Tune in for a frank and thought-provoking conversation about why family planning needs a place in medical education.

Thank you to our production team: Sonika Kumari and Julia Wong (Show Hosts), Tesam Ahmed (Content Creator), Emily Forster (Science Writer), Angela Dela Cruz (Audio Editing), Saleena Zedan (Graphic design and Promotions), and Nicole Chu (Executive Producer).

Thank you to the Institute of Medical Sciences, University of Toronto for the support in this episode production. 

In this episode, we follow the story of Mr. Patel, who underwent life-changing surgery after an oral cancer diagnosis that affected his tongue. Mr. Patel offers an unfiltered look at his recovery and reflects on how stigma shaped his experience with diagnosis and healing. Alongside him, we hear from Dr. Christopher Yao, a head and neck reconstructive surgeon advancing innovations in cancer care and reconstruction, and Dr. Rosemary Martino, a speech-language pathologist and researcher leading new approaches to swallowing recovery and rehabilitation for patients like Mr. Patel.

Thank you to our production team: Vicky Li (Audio Engineer), Areej Mir (Social Media), and Noor Al Kaabi (Show Host and Executive Producer)

Otolaryngology - Head and Neck Surgery, University Health Network

UHN Otolaryngology Instagram

Swallowing Lab

 

In this episode, Noor sits down with Dr. Tony Eskander, head and neck surgeon and scientist at the University of Toronto, to unpack the evolving landscape of head and neck cancers. Once primarily associated with smoking and alcohol, these cancers are increasingly linked to HPV, particularly in younger patients, a shift that’s reshaping how we think about risk, equity, and prevention.

Dr. Eskander breaks down the various kinds of head and neck cancers, from oral cavity to nasopharyngeal cancers, and highlights how different populations are disproportionately affected.  Tune in for the first episode of our Head & Neck Cancer series.

Production Team: Noor Al Kaabi (Show Host and Executive Producer), Vicky Li (Audio Engineer), Areej Mir (Promotions)

Eskander Lab

The idea of a vaccine against cancer may seem like science fiction, but in the case of HPV vaccines, it is a reality that has existed for over a decade. Human papillomavirus (HPV) is the most common type of sexually transmitted infection and can cause 6 different types of cancer, affecting people of all genders. HPV vaccination programs have been implemented in many countries worldwide in an effort to reduce cancer incidence, with some very newsworthy results. In this episode, hosts Braeden and Hannah describe a population study that made headlines in 2024 for reporting zero cases of cervical cancer in women vaccinated as part of Scotland's national vaccination program that began in 2008. To learn more about HPV vaccines in the Canadian context, Braeden and Hannah interview Dr. Nancy Durand, associate professor at the University of Toronto and specialist in HPV-related diseases. Dr. Durand reviews the link between HPV and cancer and the history of the HPV vaccine. She discusses HPV vaccination programs in Canada, barriers to vaccine uptake, and the strategies being implemented to increase vaccine coverage across the country. Tune in to hear about the remarkable impact of the HPV vaccine and the ongoing effort to eliminate HPV-related diseases.

The human microbiome has been a hot topic of discourse – but what do we really know about it? This diverse ecosystem of microbes can be thought of as its own organ, interacting and influencing many physiological processes. Understanding what contributes to its strong formation is a multi-disciplinary and growing field of research. To learn more about the human gut microbiome in its earliest stages of formation, we sought the expertise of Zahra Pakzad, PhD Candidate at the University of British Columbia; Dr. Marie-Claire Arrieta, Associate Professor at the University of Calgary; and Dr. Meghan Azad, Associate Professor at the University of Manitoba. In this episode, they walk us through a series of early life milestones – starting as early as birth itself – that dictate the development of this complex and microscopic system of the body. They also discuss how the microbiome impacts the immune system and share their hopes for future research in this field. Tune in to this episode to learn more about how such tiny microbes can have a big impact on our health!